James Whitsitt (1771-1849) was pastor of the Mill Creek Baptist Church for over fifty years until his resignation in 1845. He was a leader among Baptists in Middle Tennessee and a champion of Baptist values. He was not afraid of controversy. He supported mission organizations in the face of the opposition of the anti-mission party. The Tennessee Baptist Convention was formed in his church. He considered the reformation movement of Alexander Campbell heretical and strongly opposed it. He was instrumental in 1820 in forming First Baptist Church of Nashville and again in 1830 after its loss to Campbell's movement.